What is metabonomics?

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Metabonomics is the study of metabolic responses to chemicals, environmental changes and diseases. 
Metabonomics is an omics extension of metabolomics. It was first appeared in 1999. 

It is "the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification". This approach originated in Imperial College London and has been used in toxicology, disease diagnosis and a number of other fields.

See Omics.org



  • Nicholson, J. K., Lindon, J. C., Holmes, E. (1999). “Metabonomics”: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 11: p.1181-1189.
  • Lindon, J.C., Holmes, E., Bollard, M.E., Stanley, E.G., and Nicholson, J.K. (2004) Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers. Vol. 9, No. 1. p.1-/31.
  • Brindle, J.T., , Antti, H., Holmes, E., Tranter, G., Nicholson, J.K., Bethell, H.W.L., Clarke, S., Schofield, P.M., McKilligan, E., Mosedale, D.E., & Grainger, D.J. (2002) Rapid and non-invasive diagnosis of the presence and severity of coronary heart disease using 1H NMR -based metabonomics. Nature Medicine. 8 (12): p.1439-1444.
  • Bollard, M.E., Stanley, E.G., Lindon, J.C., Nicholson, J.K., & Holmes, E. (2005) NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed. 2005: p.18:143–162
  • Clayton TA, et al. Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature. 2006 Apr 20;440(7087):1073-7.
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